Treatment

Advanced Prostate Cancer Treatments Available in Canada

LEARN ABOUT TREATMENT OPTIONS FOR ADVANCED PROSTATE CANCER

There are many different treatment options for advanced prostate cancer. Not all treatment options are right for all patients. Talk with your healthcare provider for complete information on advanced prostate cancer and available treatment options.

As with all treatments, there are possible side effects.
Talk to your healthcare team to learn how to minimize and manage side effects.

To download the content on androgen deprivation therapy most frequently used in Canada, click below.

icon Download Androgen
Deprivation Therapy Content

Advanced Prostate Cancer Pharmacological Treatments in Canada

Hormone Therapies
(including Androgen Deprivation Therapy)
Chemotherapies
Targeted Therapies
Radiopharmaceutical Therapy
LHRH Agonists (Androgen Deprivation Therapy)
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PrEligard® (leuprolide acetate)

icon Given as a subcutaneous injection (under your skin)

icon Depending on dose strength, dosing schedule can be 2 injections per year (every 6 months), 3 injections per year (every 4 months), 4 injections per year (every 3 months), or 12 injections per year (every month)

icon Injections are given using a 20-gauge needle (for monthly, 3-month, and 4-month doses) or an 18-gauge needle (for 6-month dose)

icon Depending on dose strength, injection volume can be 0.25 to 0.5 mL

PrLupron® (leuprolide acetate)

icon Given as an intramuscular injection (into your muscle)

icon Depending on dose strength, dosing schedule can be 3 injections per year (every 4 months), 4 injections per year (every 3 months), or 12 injections per year (every month)

icon Injections are given using a 23-gauge needle (for 3-month, and 4-month doses)

icon Depending on dose strength, injection volume can be 1 to 1.5 mL

PrTrelstar® (triptorelin)

icon Given as an intramuscular injection (into your muscle)

icon Depending on dose strength, dosing schedule can be 2 injections per year (every 6 months), 4 injections per year (every 3 months), or 12 injections per year (every month)

icon Injections are given using a 21-gauge needle (for monthly, 3-month, and 6-month doses)

icon Injection volume is 2 mL

PrZoladex® (goserelin acetate)

icon Given as a deep subcutaneous injection (under your skin) into the anterior abdominal wall

icon Dosing schedule is 4 injections per year (every 3 months), or 12 injections per year (every month)

icon Injections are given using a 16-gauge needle

LHRH Antagonists (Androgen Deprivation Therapy)
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PrFirmagon® (degarelix)

icon Given as a subcutaneous injection (under your skin) in the abdominal region

icon Higher starting dose given as 2 separate injections

icon One month after the starting dose, dosing schedule is 12 injections per year (every month)

icon Injections are given using a 25-gauge needle (for starting and monthly doses)

icon Depending on dose strength, injection volume can be 3 to 4 mL

PrOrgovyx® (relugolix)

iconComes in tablet form taken orally

iconHigher starting dose given as 3 tablets on the first day

icon After first day, dosing schedule is 365 tablets per year (once daily) as 1 tablet per dose

icon Taken with or without food at approximately the same time each day

Androgen Synthesis Inhibitors
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PrZytiga® (abiraterone acetate)

icon Comes in tablet form taken orally

icon Dosing schedule is 365 doses per year (once daily) as either 2 or 4 tablets per dose (depending on dose strength)

icon Must be taken on an empty stomach (no solid or liquid food should be taken for 2 hours before and 1 hour after each dose)

Anti-androgen
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PrBicalutami®

iconComes in tablet form taken orally

icon Dosing schedule is 365 doses per year (once daily) as 1 tablet per dose

iconTaken with or without food

PrErleada® (apalutamide)

iconComes in tablet form taken orally

icon Dosing schedule is 365 doses per year (once daily) as either 1 or 4 tablets per dose (depends on dose strength)

iconTaken with or without food

PrFlutamide®

iconComes in tablet form taken orally

icon Dosing schedule is 1095 doses per year (3 times daily) as 1 tablet per dose

iconTaken with or without food

PrNubeqa® (darolutamide)

iconComes in tablet form taken orally

icon Dosing schedule is 730 doses per year (twice daily) as 2 tablets per dose

icon Should be taken with food at approximately the same times each day

PrXtandi® (enzalutamide)

iconComes in tablet form taken orally

icon Dosing schedule is 365 doses per year (once daily) as 4 tablets per dose

icon Taken with or without food

Chemotherapies
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PrCabazitaxel®

iconGiven as an intravenous infusion (into your vein)

iconDosing schedule is a 1-hour infusion every 3 weeks

PrDocetaxel®

iconGiven as an intravenous infusion (into your vein)

icon Dosing schedule is a 1-hour infusion every 3 weeks

Targeted Therapies
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PrAkeega (niraparib and abiraterone acetate)

icon Comes in tablet form taken orally

icon Dosing schedule is 365 doses per year (once daily) as 2 tablets per dose

icon Must be taken on an empty stomach (no solid or liquid food should be taken for 2 hours before and 1 hour after each dose) at approximately the same time each day

PrLynparza® (olaparib)

icon Comes in tablet form taken orally

icon Dosing schedule is 730 doses per year (twice daily) as 2 tablets per dose

icon Taken with or without food

Radiopharmaceutical Therapy
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Pluvicto® (lutetium-177)

iconGiven as an intravenous infusion (into your vein)

iconDosing schedule is every 6 weeks for up to 6 doses

Xofigo® (radium-223)

iconGiven as an intravenous infusion (into your vein)

iconDosing schedule is every 4 weeks for up to 6 doses


Non-Pharmacological Treatments
Radiation Therapy
Radiation Therapy uses high energy x-rays or other forms of radiation to kill cancer cells or prevent them from growing.
External beam radiation therapy
  • Involves the use of a machine that emits targeted radiation at cancer cells
  • Procedure may be multiple times per week (depends on individual treatment plan)
  • Performed by a team of healthcare professionals with specialized roles
Brachytherapy
  • Involves the placement of controlled radioactive materials inside or near a tumour
  • Procedure may be multiple times per week, multiple times per month, or once for permanent placements (depends on individual treatment plan)
  • Performed by an oncology physician
Surgery
Surgery is often used to treat localized cancer (cancer that hasn’t spread outside of the prostate).
There are different types of surgery that your healthcare team will consider based on your cancer:
Radical prostatectomy
  • Involves removal of the entire prostate gland and some tissues around it
  • Typically a one-time procedure requiring hospital stay for 1–3 days
  • Performed by a surgeon and healthcare team
Transurethral resection of the prostate
  • Involves removal of the inner part of the prostate gland through the urethra
  • Typically a one-time procedure requiring hospital stay for 1–2 nights
  • Performed by a surgeon and healthcare team
Orchiectomy
  • Involves surgical removal of one or both testes
  • Typically a one-time procedure with no hospital stay required
  • Performed by a surgeon and healthcare team